PROTOCOLOS CLÍNICOS E DIRETRIZES TERAPÊUTICAS

Protocolos Clínicos e Diretrizes Terapêuticas duração e a monitorização do tratamento, bem como a verificação periódica das doses prescritas e dispensadas, a adequação de uso do medicamento e dos critérios de interrupção do tratamento. Recomenda-se que as pacientes sejam atendidas por especialistas em Genética ou Endocrinologia e que sejam monitorizados os efeitos adversos e benefícios a longo prazo em serviços especializados. 11 T ermo de esclarecimento e responsabilidade – TER É obrigatória a informação à paciente ou a seu responsável legal dos potenciais riscos, benefícios e efeitos adversos relacionados ao uso do medicamento preconizado neste protocolo. O TER é obrigatório ao se prescrever medicamento do Componente Especializado da Assistência Farmacêutica. 12 R eferências bibliográficas 1. Saenger P. Turner’s Syndrome. N Engl J Med. 1996;335(23):1749-54. 2. Nussbaum RL, McInnes RR, Willand HF. Thompson & Thompson Genetics in Medicine. 6th ed. Philadelphia: WB Saunders; 2001. 3. Saenger P, Wikland KA, Conway GS, Davenport M, Gravholt CH, Hints R, et al. Recommendations for the Diagnosis and Management of Turner Syndrome. J Clin Endocrionol Metab. 2001;86(7):3061-9. 4. Rochiccioli P, David M, Malpuech G, Colle M, Limal JM, Battin J, et al. Study of final height in Turner’s syndrome: ethnic and genetic influences. Acta Paediatr. 1994;83(3):305-8. 5. Guidelines for the use of growth hormone in children with short stature. A report by the Drug and Therapeutics Committee of the Lawson Wilkins Pediatric Endocrine Society. J Pediatr. 1995;127(6):857-67. 6. Gault EJ, Donaldson MDC. Efficacy of growth hormone therapy in Turner’s syndrome [Internet]. Bristol: BSPED; [cited 2003 Jun 13]. Available from: http://www.bsped.org.uk/professional/position/docs/turner.htm. 7. Cave CB, Bryant J, Milne R. Recombinant growth hormone in children and adolescents with Turner’s syndrome. Cochrane Database Syst Rev. 2003;(3):CD003887. 8. Gharib H, Cook DM, Saenger PH, Bengtsson BA, Feld S, Nippoldt TB, et al. American Associaton of Clinical Endocrinologists medical guidelines for clinical practice for growth hormone use in adults and children – 2003 update. Endocr Pract. 2003;9(1):65-76. 9. Baxter L, Bryant J, Cave CB, Milne R. Recombinant growth hormone for children and adolescents with Turner syndrome. Cochrane Database Syst Rev. 2007;(1):CD003887. Update of: Cochrane Database Syst Rev. 2003;(3):CD003887. 10. Stephure DK, Holland FJ, Alexander D, Bailey J, Best T, Boulton BC, et al. Human growth hormone and low dose ethinyl estradiol treatment in Turner syndrome: a prospective randomized controlled trial to final height. In: Hibi I, Takano K, editors. Basic and clinical approach to Turner syndrome. Amsterdam: Elsevier; 1993. p. 287-91. 11. Stephure DK; CanadianGroth HormoneAdvisory Committee. Impact of Growth Hormone Supplementation onAdult Height in Turner Syndrome: Results of the Canadian Randomised Controlled Trial. J Clin Endocrinol Metab. 2005;90(6):3360-6. Epub 2005 Mar 22. 12. Rosenfeld RG. Acceleration of growth in Turner Syndrome patients treated with growth hormone: summary of three years results. J Endocrinol Invest. 1989;12(8 Suppl 3):49-51. 13. Kollmann F, Damm M, Reinhardt D, Stover B, Heirich U, Brendel L, et al. Growth-promoting effects of human recombinant growth hormone in subjects with Ullrich-Turner syndrome (UTS). In: Ranke MB, Rosenfeld RG, editors. Turner Syndrome: Growth Promoting Therapies. Vol. 924, Amsterdam: Elsevier; 1991. p. 201-7. 14. Quigley CA, Crowe BJ, Anglin DG, Chipman JJ. Growth hormone and low dose estrogen in Turner Syndrome: results of a United States multi-center trial to near-final height. J Clin Endocrinol Metab. 2002;87(5):2033-41. 15. Davenport ML, Crowe BJ, Travers SH, Rubin K, Ross JL, Fechner PY, et al. Growth hormone treatment of early growth failure in toddlers with Turner syndrome: a randomized, controlled, multicenter trial. J Clin Endocrinol Metab. 2007;92(9):3406-16. Epub 2007 Jun 26. 16. Rovet J, Holland J. Psychological aspects of the Canadian randomized controlled trial of human growth hormone and low dose ethinyl estradiol in children with Turner Syndrome. Horm Res. 1993;39(Suppl 2):60-4. 17. Ross JL, Feuillan P, Kushner H, Roeltgen D, Cutler GB Jr. Abscense of growth hormone effects on cognitive function in girls with Turner Syndrome. J Clin Endocrinol Metab. 1997;82(6):1814-7. 18. Van Pareren YK, Duivenvoorden HJ, Slijper FM, Koot HM, Drop SL, de Muinck Keizer-Schrama SM. Psychosocial functioning after discontinuation of long-term growth hormone treatment in girls with Turner syndrome. Horm Res. 2005;63(5):238-44. Epub 2005 May 17. 566